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KMID : 0383820100680050294
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Tuberculosis and Respiratory Diseases
2010 Volume.68 No. 5 p.294 ~ p.297
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A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PMⓡ Infusion
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Kim Hyung-Kyung
Kim Seo-Woo
Kang Hye-Won
kwon Kyoung-Joo
Park Hye-Sung
Ryu Yon-Ju
Lee Jin-Hwa
Chun Eun-Mi
Cho Young-Joo
Chang Jung-Hyun
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Abstract
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Although Taxolⓡ is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, “C activation-related pseudo-allergy”. Most severe hypersenstivity reactions occur within the first few minutes of Taxolⓡ administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PMⓡ infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PMⓡ infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.
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KEYWORD
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Hypersensitivity, Delayed, Anaphylaxis, Purpura, Paclitaxel
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